Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937727 | 0.83 | ACE (0.35) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937745 | 0.80 | TRPV1 (0.35) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937588 | 0.71 | ACE (0.48) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937665 | 0.70 | ACE (0.47) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937679 | 0.69 | BRD4 (0.51) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937732 | 0.68 | ACE (0.44) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937538 | 0.68 | PER2 (0.45) | CYP2D6CYP2C19CYP2C9KMT2ACYP1A2 | |
| SCHEMBL30937524 | 0.68 | ACE (0.44) | ACEMMP13CYP2D6CYP2C19POLB | |
| SCHEMBL30937518 | 0.67 | DPP4 (0.38) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL8345781 | 0.66 | TSHR (0.39) | ACEMMP13CYP2D6CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |