Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937538 | 0.82 | PER2 (0.45) | MAPK1ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL30937552 | 0.80 | PLA2G10 (0.38) | DPP4MAPK1PER2PDE4APDE4B | |
| SCHEMBL30937732 | 0.77 | ACE (0.44) | DPP4MAPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL30937679 | 0.75 | BRD4 (0.51) | KDM4EALDH1A1KMT2AACEMMP13 | |
| SCHEMBL30937655 | 0.74 | ALDH1A1 (0.45) | MAPK1ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL30937651 | 0.74 | ACE (0.53) | KDM4EMEN1ALDH1A1KMT2ARAB9A | |
| SCHEMBL30937524 | 0.74 | ACE (0.44) | MAPK1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL31120591 | 0.71 | ACE (0.45) | MAPK1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL30937558 | 0.71 | KDM4E (0.34) | MAPK1ITGB3ITGA2BKDM4EMEN1 | |
| SCHEMBL6018448 | 0.70 | CA2 (0.41) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |