Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937608 | 0.82 | ACE (0.42) | ACEMMP13POLBKDM4EMAPK1 | |
| SCHEMBL30937632 | 0.81 | ACE (0.40) | ACEMMP13LMNAKDM4EMAPK1 | |
| SCHEMBL30937665 | 0.75 | ACE (0.47) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL30937732 | 0.72 | ACE (0.44) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL30937524 | 0.72 | ACE (0.44) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL30937651 | 0.72 | ACE (0.53) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL30937579 | 0.71 | ACE (0.40) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL31120592 | 0.70 | CA12 (0.37) | POLBPTGDR2LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL30937681 | 0.70 | ACE (0.42) | ACEMMP13CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL31120591 | 0.70 | ACE (0.45) | ACEMMP13CYP2D6CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |