Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811008 | 1.00 | ROCK2 (0.39) | ROCK2MALT1CYP19A1CA2NOS3 | |
| Hydrochloric Acid SCHEMBL21810886 | 0.98 | ROCK2 (0.38) | ROCK2MALT1CYP19A1CA2NOS3 | |
| SCHEMBL21810881 | 0.79 | HTR7 (0.35) | — | |
| SCHEMBL3983842 | 0.79 | KDM1A (0.40) | MALT1CYP19A1CA2 | |
| SCHEMBL431457 | 0.79 | HRH4 (0.39) | ROCK2CYP19A1CA2 | |
| SCHEMBL21810889 | 0.79 | HRH4 (0.39) | ROCK2CYP19A1CA2 | |
| SCHEMBL21810882 | 0.79 | HTR7 (0.35) | — | |
| SCHEMBL16303421 | 0.79 | MALT1 (0.40) | ROCK2MALT1CYP19A1TRPV1 | |
| SCHEMBL23652982 | 0.78 | AADAT (0.40) | — | |
| SCHEMBL9692474 | 0.78 | TRPV1 (0.46) | ROCK2MALT1CYP19A1CA2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |