SCHEMBL30940774

SCHEMBL30940774

Nc1ncnc2c1c(Br)cn2[C@@H]1C[C@H](C(=O)NC[C@H]2CCCNC2)[C@@H](O)[C@H]1O

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 18/20 0.53
▸ PRMT5 O14744 2/20 0.42
▸ WDR77 Q9BQA1 2/20 0.42
▸ ADK P55263 1/20 0.40
▸ MTOR P42345 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ METTL14 Q9HCE5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25047947 1.00 METTL3 (0.53) METTL3PRMT5WDR77ADKMTOR
SCHEMBL30940846 1.00 METTL3 (0.53) METTL3PRMT5WDR77ADKMTOR
SCHEMBL25048359 1.00 METTL3 (0.53) METTL3PRMT5WDR77ADKMTOR
SCHEMBL30941080 0.85 METTL3 (0.57) METTL3ADK
SCHEMBL25047957 0.85 METTL3 (0.57) METTL3ADK
SCHEMBL30940749 0.85 METTL3 (0.57) METTL3ADK
SCHEMBL25048440 0.85 METTL3 (0.57) METTL3ADK
SCHEMBL25047977 0.85 METTL3 (0.43) METTL3PRMT5WDR77ADK
SCHEMBL25047851 0.78 METTL3 (0.50) METTL3ADKMTOR
SCHEMBL25047812 0.75 ADORA3 (0.42) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2025-06-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION KMT5A, KMT5B, KMT5C METTL3 166/4885PRMT5 17/4885WDR77 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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