Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 2/20 | 0.65 |
| ▸ | PNP | P00491 | 3/20 | 0.63 |
| ▸ | HPRT1 | P00492 | 12/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | POLA1 | P09884 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | HBB | P68871 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630250 | 1.00 | POLG (0.65) | POLGPNPHPRT1POLBPOLA1 | |
| SCHEMBL15630219 | 0.99 | PNP (0.64) | POLGPNPHPRT1POLBPOLA1 | |
| Ammonia Solution, Strong SCHEMBL7750989 | 0.92 | POLG (0.66) | POLGPNPHPRT1POLBPOLA1 | |
| SCHEMBL15630285 | 0.91 | HPRT1 (0.67) | POLGPNPHPRT1USP2TSHR | |
| SCHEMBL15630242 | 0.87 | POLG (0.70) | POLGPNPHPRT1POLBPOLA1 | |
| Penciclovir Triphosphate SCHEMBL1664402 | 0.87 | POLG (0.65) | POLGPNPHPRT1POLBPOLA1 | |
| Penciclovir Triphosphate SCHEMBL30945294 | 0.87 | POLG (0.65) | POLGPNPHPRT1POLBPOLA1 | |
| SCHEMBL15630235 | 0.86 | PNP (0.69) | POLGPNPHPRT1POLBPOLA1 | |
| Omaciclovir SCHEMBL571367 | 0.83 | HPRT1 (0.66) | PNPHPRT1USP2TSHREDNRA | |
| SCHEMBL10506595 | 0.83 | TK1 (0.65) | PNPHPRT1USP2TSHREDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8748177-B2 | Compositions for proliferation of cells and related methods | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-06-10 | — | — | US | disclosed |
| EP-2598150-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | The Hospital For Sick Children (CA) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018643-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2012-02-09 | — | — | WO | disclosed |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-12-08 | — | — | US | disclosed |
| WO-2010039679-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | POLG 176/4885PNP 3880/4885HPRT1 2747/4885 |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | POLG 176/4885PNP 3880/4885HPRT1 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.