Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | IL4I1 | Q96RQ9 | 5/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27163582 | 0.86 | IL4I1 (0.62) | TP53IL4I1HSD11B1LMNARXFP1 | |
| SCHEMBL30046438 | 0.86 | IL4I1 (0.62) | TP53IL4I1HSD11B1LMNARXFP1 | |
| SCHEMBL30947950 | 0.83 | IL4I1 (0.66) | TP53IL4I1LMNAROCK2 | |
| SCHEMBL30948084 | 0.81 | IL4I1 (0.63) | TP53IL4I1ROCK2 | |
| SCHEMBL27163155 | 0.79 | TP53 (0.54) | TP53IL4I1LMNA | |
| SCHEMBL30948100 | 0.79 | IL4I1 (0.48) | TP53IL4I1ROCK2 | |
| SCHEMBL30948290 | 0.79 | IL4I1 (0.48) | IL4I1ROCK2 | |
| SCHEMBL30948184 | 0.78 | IL4I1 (0.56) | TP53IL4I1HSD11B1LMNARXFP1 | |
| SCHEMBL30948237 | 0.78 | IL4I1 (0.45) | TP53IL4I1HSD11B1LMNARXFP1 | |
| SCHEMBL30948302 | 0.78 | TP53 (0.43) | TP53IL4I1HSD11B1LMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | IL4I1, IL4, IL2 | TP53 1444/4885IL4I1 1/4885HSD11B1 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.