Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IL4I1 | Q96RQ9 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948281 | 0.86 | IL4I1 (0.47) | RAB9AKDM4EHTTNPC1SMN1; SMN2 | |
| SCHEMBL30948202 | 0.85 | IL4I1 (0.40) | KDM4ESMN1; SMN2LMNAIL4I1MAPT | |
| SCHEMBL30948222 | 0.83 | IL4I1 (0.45) | LMNAIL4I1CYP11B1CYP11B2POLB | |
| SCHEMBL30948180 | 0.83 | KDM4E (0.38) | RAB9AKDM4EHTTNPC1SMN1; SMN2 | |
| SCHEMBL30948210 | 0.83 | RAB9A (0.39) | RAB9AKDM4EHTTNPC1SMN1; SMN2 | |
| SCHEMBL30948072 | 0.82 | IL4I1 (0.39) | RAB9ANPC1SMN1; SMN2PKMIL4I1 | |
| SCHEMBL30948040 | 0.82 | IL4I1 (0.43) | RAB9AIL4I1 | |
| SCHEMBL30948054 | 0.82 | IL4I1 (0.52) | RAB9ANPC1ALDH1A1PKMIL4I1 | |
| SCHEMBL30948387 | 0.80 | RAB9A (0.37) | RAB9AKDM4EHTTNPC1SMN1; SMN2 | |
| SCHEMBL30948297 | 0.80 | CA12 (0.45) | HTTSMN1; SMN2IL4I1MAPTCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246937-A1 | IL4I1 INHIBITORS AND METHODS OF USE | IL4I1, IL4, IL2 | RAB9A 3769/4885KDM4E 1134/4885HTT 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.