Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 16/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 14/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056172 | 0.90 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL7722748 | 0.90 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL3142423 | 0.90 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL7722895 | 0.90 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL30325576 | 0.90 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL30948949 | 0.89 | GABRA3 (0.50) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2845958 | 0.81 | GABRG2 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL23819814 | 0.80 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL19891697 | 0.80 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL30255417 | 0.80 | GABRA5 (0.77) | GABRA5GABRG2GABRB3GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024077061-A2 | GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL SMOOTH MUSCLE CONTRACTION AND INFLAMMATION | UWM RESEARCH FOUNDATION, INC. (US) | 2024-04-11 | — | — | WO | disclosed |