Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23625920 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL23626139 | 0.95 | MAPT (0.41) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL30039556 | 0.95 | MAPT (0.41) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL24823372 | 0.93 | ALDH1A1 (0.34) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL23625928 | 0.89 | ULK1 (0.35) | MAPTL3MBTL1PGRMEN1KMT2A | |
| SCHEMBL30952916 | 0.89 | ULK1 (0.35) | MAPTL3MBTL1PGRMEN1KMT2A | |
| SCHEMBL24852676 | 0.87 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL24824225 | 0.76 | KDM4E (0.35) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL24852671 | 0.76 | MEN1 (0.42) | KDM4EALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL24852950 | 0.74 | PRKCI (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767090-B | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-05-28 | — | — | CN | disclosed |