Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.73 |
| ▸ | RAB9A | P51151 | 12/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.73 |
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.73 |
| ▸ | HPGD | P15428 | 6/20 | 0.73 |
| ▸ | GLA | P06280 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.54 |
| ▸ | RELA | Q04206 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24106599 | 1.00 | NPC1 (0.73) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL2244352 | 0.98 | NPC1 (0.76) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL17199120 | 0.89 | NPC1 (0.81) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL10590678 | 0.89 | SMN1; SMN2 (0.61) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL23748392 | 0.88 | NPC1 (0.73) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL28292707 | 0.87 | RAB9A (0.96) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL1734841 | 0.86 | NPC1 (0.76) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL23748387 | 0.86 | SMN1; SMN2 (0.71) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL29622897 | 0.86 | NPC1 (0.76) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL5655662 | 0.85 | NPC1 (0.86) | NPC1RAB9AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | SQSTM1, MCL1, HSPA2 | NPC1 1454/4885RAB9A 701/4885KDM4E 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.