SCHEMBL30965757

SCHEMBL30965757

CCCCOC(=O)NC1CCN(CCN2CCN(c3cc(OC)c(NC4CCC(=O)NC4=O)cc3F)CC2)CC1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 7/20 0.44
DDB1 Q16531 3/20 0.41
DRD2 P14416 7/20 0.37
DRD4 P21917 7/20 0.37
DRD3 P35462 7/20 0.37
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
HTR4 Q13639 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965523 0.95 CRBN (0.46) CRBNDDB1DRD2CHRM1
SCHEMBL30965618 0.89 CRBN (0.45) CRBNDDB1DRD2DRD4DRD3
SCHEMBL30965564 0.83 CRBN (0.48) CRBNDDB1DRD2DRD4DRD3
SCHEMBL30965703 0.83 CRBN (0.42) CRBNDDB1DRD2DRD3
SCHEMBL30965580 0.82 CHRM4 (0.43) CRBNDDB1DRD2DRD4DRD3
SCHEMBL27225107 0.81 DRD2 (0.48) CRBNDDB1DRD2DRD4DRD3
SCHEMBL30965558 0.80 DRD2 (0.45) CRBNDDB1DRD2DRD3
SCHEMBL30965691 0.80 CRBN (0.41) CRBNDDB1DRD2DRD4DRD3
SCHEMBL30965763 0.80 CRBN (0.49) CRBNDDB1
SCHEMBL30965521 0.77 CRBN (0.47) CRBNDDB1DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658658-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND Uppthera, Inc. (KR) 2025-12-10 EP disclosed
WO-2024162828-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2024-08-08 WO disclosed