Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HK1 | P19367 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.44 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14794998 | 0.84 | POLB (0.54) | POLBALDH1A1HTT | |
| SCHEMBL29178285 | 0.80 | CA12 (0.58) | POLBALDH1A1HTTUSP2CYP1A2 | |
| SCHEMBL5570739 | 0.78 | KMT2A (0.55) | POLBSIGMAR1HRH1CCR3STS | |
| SCHEMBL26680373 | 0.75 | ITGB3 (0.65) | HTR6SIGMAR1KAT6AALDH1A1USP2 | |
| SCHEMBL29178269 | 0.75 | NPC1 (0.59) | POLBALDH1A1ALOX15CYP1A2 | |
| SCHEMBL29178289 | 0.75 | SMN1; SMN2 (0.57) | ALDH1A1HTTSTS | |
| SCHEMBL15577834 | 0.74 | P2RY12 (0.40) | POLBALDH1A1HTTHRH1CCR3 | |
| SCHEMBL7362762 | 0.73 | HTR6 (0.55) | HTR6SIGMAR1KAT6AALDH1A1HTT | |
| SCHEMBL656655 | 0.73 | POLB (0.97) | POLBSIGMAR1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7504156 | 0.72 | POLB (0.93) | POLBSIGMAR1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221633-A | TRPV1/URAT1 dual inhibitor, preparation method and application thereof | 郑州大学第一附属医院 | 2024-06-21 | — | — | CN | claimed |
| CN-118221633-A | TRPV1/URAT1 dual inhibitor, preparation method and application thereof | 郑州大学第一附属医院 | 2024-06-21 | — | — | CN | disclosed |