Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30967452 | 0.84 | MCHR1 (0.40) | KDM4EHSD17B10MAPK1MCHR1HTT | |
| SCHEMBL30967561 | 0.82 | HSD17B10 (0.40) | KDM4EHSD17B10MAPK1MCHR1HTT | |
| SCHEMBL18416893 | 0.81 | CYP3A4 (0.56) | KDM4EHSD17B10HTTALDH1A1MAPT | |
| SCHEMBL30189863 | 0.81 | CYP3A4 (0.56) | KDM4EHSD17B10HTTALDH1A1MAPT | |
| SCHEMBL25323852 | 0.76 | KDM4E (0.68) | KDM4EHSD17B10MAPK1HTTALDH1A1 | |
| SCHEMBL106320 | 0.75 | ALDH1A1 (0.55) | HSD17B10MAPK1HTTALDH1A1MAPT | |
| SCHEMBL30967498 | 0.75 | TLR8 (0.49) | KDM4EHSD17B10MCHR1ALDH1A1MAPT | |
| SCHEMBL19729118 | 0.73 | HSD17B10 (0.55) | KDM4EHSD17B10MCHR1HTTALDH1A1 | |
| SCHEMBL30967564 | 0.71 | SMN1; SMN2 (0.41) | KDM4EHSD17B10MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL5206462 | 0.70 | ALDH1A1 (0.56) | HSD17B10HTTALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615838-A1 | SUBSTITUTED BI-AND TRICYCLIC HSET INHIBITORS | Merck Patent GmbH (DE) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024099898-A1 | SUBSTITUTED BI-AND TRICYCLIC HSET INHIBITORS | MERCK PATENT GMBH (DE) | 2024-05-16 | — | — | WO | disclosed |