Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087897 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL27770289 | 0.78 | CA12 (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL688062 | 0.76 | CDC7 (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL2958703 | 0.73 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL13149663 | 0.73 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL3093242 | 0.72 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL3377969 | 0.71 | BCAT2 (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGMGLL | |
| SCHEMBL323044 | 0.71 | NOTUM (0.55) | MAP4K4MGLLKDM4EALDH1A1MAPK1 | |
| SCHEMBL3342457 | 0.70 | LRRK2 (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL10365452 | 0.70 | CYP3A4 (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799810-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20100120865-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-05-13 | — | — | US | disclosed |
| EP-2035413-A2 | THIAZOLYL UREA DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Novartis AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008000421-A2 | THIAZOLYL UREA DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120865-A1 | Organic compounds | PIK3C3, PIK3R3, PIK3R4 | PIK3CD 10/4885PIK3CA 5/4885PIK3CB 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.