SCHEMBL30970486

SCHEMBL30970486

Cc1ccc(S(=O)(=O)O)c(-c2cc(-c3cc(C)ccc3S(=O)(=O)O)c(C(=O)N3Cc4cccc(N)c4C3)c(OCc3ccccc3)c2C)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.33
GLRA1 P23415 1/20 0.33
MEN1 O00255 4/20 0.32
KMT2A Q03164 4/20 0.32
SLC6A9 P48067 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31
TRAP1 Q12931 2/20 0.31
HSP90B1 P14625 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31
MMP1 P03956 1/20 0.31
MMP2 P08253 1/20 0.31
MMP7 P09237 1/20 0.31
MMP9 P14780 1/20 0.31
MMP12 P39900 1/20 0.31
MMP14 P50281 1/20 0.31
MMP15 P51511 1/20 0.31
MMP16 P51512 1/20 0.31
MMP26 Q9NRE1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30970485 1.00 HSP90AA1 (0.33) HSP90AA1GLRA1MEN1KMT2ASLC6A9
SCHEMBL30301748 0.91 TRAP1 (0.35) HSP90AA1GLRA1MEN1KMT2ASLC6A9
SCHEMBL30301766 0.91 TRAP1 (0.37) HSP90AA1GLRA1MEN1KMT2ASLC6A9
SCHEMBL30970490 0.88 TRAP1 (0.33) HSP90AA1MEN1KMT2ASLC6A9TRAP1
SCHEMBL30368511 0.86 TRAP1 (0.34) SLC6A9TRAP1HSP90B1MRGPRX4
SCHEMBL30970483 0.85 CCNA2 (0.34)
SCHEMBL30970487 0.85 CCNA2 (0.34)
SCHEMBL30368302 0.83 PDE4D (0.34) TRAP1HSP90B1ALDH1A1KDM4EFFAR1
SCHEMBL30156708 0.81 PTGDR2 (0.38) MEN1KMT2APTGDR2MMP1MMP2
SCHEMBL30958001 0.79 CHRM3 (0.37) HSP90AA1MEN1KMT2AHSP90B1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118317949-A Isoindolines as PMS2 inhibitors 奈奥芬莱有限公司 2024-07-09 CN disclosed