Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27002463 | 1.00 | ADORA1 (0.38) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL27002343 | 0.87 | PRMT5 (0.45) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL29915218 | 0.85 | POLB (0.46) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL27002563 | 0.85 | POLB (0.46) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL30752919 | 0.81 | PARP1 (0.32) | PARP1 | |
| SCHEMBL27002499 | 0.81 | ADORA1 (0.41) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL31496929 | 0.81 | PRMT5 (0.34) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL23087286 | 0.80 | ADORA1 (0.39) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL29915065 | 0.79 | PRMT5 (0.61) | PRMT5WDR77PARP1GAA | |
| SCHEMBL27002364 | 0.79 | PRMT5 (0.61) | PRMT5WDR77PARP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | MIRATI THERAPEUTICS INC (US) | 2024-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | PRMT1, PRMT5, PRMT6 | ADORA1 3288/4885PDE1A 757/4885PDE1B 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.