Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26634636 | 0.95 | TGM2 (0.60) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL22984651 | 0.85 | HTT (0.63) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL13092424 | 0.83 | LMNA (0.55) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL18254066 | 0.82 | HTT (0.81) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL19606708 | 0.82 | HTT (0.59) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL17532634 | 0.81 | LMNA (0.79) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL9874334 | 0.81 | HTT (0.79) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL15346534 | 0.81 | HTT (0.79) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL9340146 | 0.81 | HTT (0.79) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL5116844 | 0.80 | HTT (0.68) | HTTLMNASMN1; SMN2TGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256098-A1 | COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2010-10-07 | — | — | US | disclosed |
| EP-2188296-A1 | COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009029844-A1 | COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256098-A1 | COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS | WAPL, WDR1, DUSP1 | HTT 3824/4885LMNA 4125/4885SMN1; SMN2 3533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.