Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 6/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999583 | 0.80 | DDX3X (0.41) | NOTUMRXRAGRIN1GRIN2BLRRK2 | |
| SCHEMBL21263902 | 0.77 | NOTUM (0.59) | NOTUMRXRAGRIN1GRIN2BPTGS2 | |
| SCHEMBL15935031 | 0.76 | HTT (0.46) | TRPV4PTGS2DHFRPTGS1MAT2A | |
| SCHEMBL18086468 | 0.76 | KDM4E (0.42) | TRPV4PTGS2DHFRPTGS1 | |
| SCHEMBL29640824 | 0.76 | MAPT (0.44) | NOTUMRXRAGRIN1GRIN2BLRRK2 | |
| SCHEMBL21275488 | 0.76 | MAPT (0.44) | NOTUMRXRAGRIN1GRIN2BLRRK2 | |
| SCHEMBL26847601 | 0.75 | TRPV4 (0.41) | TRPV4PTGS2DHFRPTGS1MAT2A | |
| SCHEMBL25043775 | 0.75 | GRIN1 (0.38) | NOTUMRXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL30343244 | 0.75 | GRIN1 (0.38) | NOTUMRXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL25408961 | 0.73 | DHFR (0.41) | TRPV4PTGS2KCNH2DHFRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118284606-A | Bicyclic amine derivatives as GABAA α5 receptor modulators | 吉瑞工厂 | 2024-07-02 | — | — | CN | disclosed |