Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496286 | 0.81 | POLB (0.49) | GPR35GAAALDH1A1SMN1; SMN2PKM | |
| SCHEMBL16397208 | 0.79 | SMN1; SMN2 (0.35) | GAAALDH1A1SMN1; SMN2HPGDPOLB | |
| SCHEMBL30982103 | 0.78 | NPSR1 (0.46) | ALDH1A1SMN1; SMN2POLBMAPTHTT | |
| SCHEMBL10175016 | 0.77 | HSD17B10 (0.44) | ALDH1A1SMN1; SMN2PKMHPGDMAPT | |
| SCHEMBL16410303 | 0.75 | ATR (0.47) | GAAPOLBKDM4EMEN1KMT2A | |
| SCHEMBL30982180 | 0.73 | MAPT (0.46) | ALDH1A1PKMHPGDPOLBMAPT | |
| SCHEMBL9976045 | 0.71 | ALDH1A1 (0.59) | GAAALDH1A1SMN1; SMN2TDP1HPGD | |
| SCHEMBL360571 | 0.71 | ALDH1A1 (0.61) | GAAALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL31215236 | 0.70 | SMN1; SMN2 (0.69) | GAAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL4327459 | 0.70 | SMN1; SMN2 (0.69) | GAAALDH1A1SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153595-A1 | CHROMANE DERIVATIVES AS EGFR SELECTIVE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-25 | — | — | WO | disclosed |