Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30982103 | 0.85 | NPSR1 (0.46) | SMN1; SMN2CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL30982180 | 0.80 | MAPT (0.46) | KMT2APOLBL3MBTL1RAB9AMEN1 | |
| SCHEMBL30982115 | 0.79 | GPR35 (0.43) | SMN1; SMN2TSHRKMT2APOLBL3MBTL1 | |
| SCHEMBL18989524 | 0.79 | CYP2C9 (0.39) | CYP1A2CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL16410303 | 0.79 | ATR (0.47) | CYP1A2KMT2APOLBL3MBTL1ATM | |
| SCHEMBL22574533 | 0.76 | MTNR1A (0.47) | SMN1; SMN2KMT2APOLBRAB9AMEN1 | |
| SCHEMBL17057294 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL5356920 | 0.73 | MEN1 (0.47) | SMN1; SMN2CYP1A2CYP2C9TSHRKMT2A | |
| SCHEMBL29215929 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2KMT2APOLBRAB9ARXFP1 | |
| SCHEMBL17607299 | 0.72 | POLB (0.41) | SMN1; SMN2KMT2APOLBGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160145247-A1 | Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof | NOVARTIS AG (CH) | 2016-05-26 | — | — | US | disclosed |
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145247-A1 | Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof | CFD, CFH, CFB | SMN1; SMN2 4625/4885CYP1A2 402/4885CYP2D6 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.