Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983814 | 1.00 | PDCD1 (0.34) | PDCD1CD274AKT1CNR1ADORA3 | |
| SCHEMBL30983843 | 0.91 | PDCD1 (0.36) | PDCD1CD274AKT1CNR1ADORA3 | |
| SCHEMBL30984006 | 0.88 | CNR1 (0.36) | CNR1PIK3CDKDM4E | |
| SCHEMBL30984001 | 0.87 | ADORA3 (0.35) | PDCD1CD274AKT1CNR1ADORA3 | |
| SCHEMBL30983914 | 0.86 | CNR1 (0.35) | CNR1ADORA3PIK3CDCNR2MC4R | |
| SCHEMBL31268895 | 0.86 | PDCD1 (0.36) | PDCD1CD274ADORA3PIK3CDTSHR | |
| SCHEMBL30984007 | 0.86 | AKT1 (0.38) | AKT1CNR1ADORA3CNR2MC4R | |
| SCHEMBL30983441 | 0.85 | PDCD1 (0.36) | PDCD1CD274PIK3CDLMNA | |
| SCHEMBL31269078 | 0.85 | CD274 (0.35) | PDCD1CD274CNR1ADORA3PIK3CD | |
| SCHEMBL30983926 | 0.83 | ADORA3 (0.35) | PDCD1CD274CNR1ADORA3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| US-12414954-B2 | POLQ inhibitors | ASTRAZENECA AB (SE) | 2025-09-16 | — | — | US | disclosed |
| US-20250195530-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| US-20240366615-A1 | POLQ INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 2024-11-07 | — | — | US | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366615-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | PDCD1 3112/4885CD274 3235/4885AKT1 1383/4885 |
| US-12414954-B2 | POLQ inhibitors | POLQ, POLG, POLB | PDCD1 3112/4885CD274 3235/4885AKT1 1383/4885 |
| US-20250195530-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | PDCD1 3112/4885CD274 3235/4885AKT1 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.