Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 12/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.68 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627655 | 0.90 | KEAP1 (0.67) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL27295108 | 0.88 | FLT1 (0.54) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL30987388 | 0.88 | FLT1 (0.54) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL30987406 | 0.84 | CCR8 (0.75) | LMNAALDH1A1SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL1340327 | 0.84 | CCR8 (0.75) | LMNAALDH1A1SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL26089402 | 0.83 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL8627716 | 0.81 | TUBB4A (0.59) | KEAP1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29892528 | 0.80 | KEAP1 (0.77) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL28841732 | 0.78 | KEAP1 (0.70) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 | |
| SCHEMBL21511039 | 0.78 | GAA (1.00) | KEAP1NFE2L2SQSTM1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024133292-A1 | NOVEL CCR8 ANTAGONISTS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-06-27 | — | — | WO | disclosed |