Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | PIM1 | P11309 | 5/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30986 | 0.79 | SMN1; SMN2 (0.36) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1818321 | 0.75 | NPC1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL8156881 | 0.74 | NPC1 (0.42) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL461580 | 0.74 | NPC1 (0.42) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30579405 | 0.70 | NPC1 (0.40) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21061310 | 0.68 | ALDH1A1 (0.39) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7455962 | 0.67 | NTRK1 (0.37) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL25317207 | 0.67 | NOS2 (0.42) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7470373 | 0.67 | PKM (0.46) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10651514 | 0.65 | NOS2 (0.55) | MAPTSMN1; SMN2KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |