Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 3/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989933 | 0.91 | P2RX7 (0.42) | MAPK1P2RX7MEN1KMT2ATAS1R3 | |
| SCHEMBL30989929 | 0.91 | P2RX7 (0.42) | MAPK1P2RX7MEN1KMT2ATAS1R3 | |
| SCHEMBL30990045 | 0.80 | GPR6 (0.38) | PDE4APDE4BPDE4DGPR6PDE4C | |
| SCHEMBL30989902 | 0.80 | GPR6 (0.38) | PDE4APDE4BPDE4DGPR6PDE4C | |
| SCHEMBL30989853 | 0.79 | PDE4A (0.54) | PDE4APDE4BPDE4DMEN1KMT2A | |
| SCHEMBL30989892 | 0.78 | NTRK1 (0.46) | MAPK1P2RX7HSD17B2GPR6 | |
| SCHEMBL30989860 | 0.78 | NTRK1 (0.39) | PDE4APDE4BPDE4DP2RX7MEN1 | |
| SCHEMBL30989956 | 0.75 | MAPK1 (0.54) | MAPK1P2RX7MEN1KMT2A | |
| SCHEMBL30989858 | 0.74 | GPR6 (0.39) | PDE4APDE4BPDE4DP2RX7GPR6 | |
| SCHEMBL1265177 | 0.73 | P2RX7 (0.47) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |