Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989933 | 1.00 | P2RX7 (0.42) | P2RX7MAPK1PTGER4GPR6CRHR1 | |
| SCHEMBL30990005 | 0.91 | MAPK1 (0.40) | P2RX7MAPK1GPR6MEN1KMT2A | |
| SCHEMBL30989892 | 0.86 | NTRK1 (0.46) | P2RX7MAPK1PTGER4GPR6CRHR1 | |
| SCHEMBL30989956 | 0.85 | MAPK1 (0.54) | P2RX7MAPK1MEN1KMT2ATRPV1 | |
| SCHEMBL30989852 | 0.81 | GPBAR1 (0.36) | GPR6JAK2JAK1JAK3 | |
| SCHEMBL30989913 | 0.81 | GPBAR1 (0.36) | GPR6JAK2JAK1JAK3 | |
| SCHEMBL30989846 | 0.78 | GPR6 (0.42) | P2RX7PTGER4GPR6CRHR1PTGER2 | |
| SCHEMBL30990021 | 0.77 | TAS1R3 (0.57) | MEN1KMT2ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL30989885 | 0.77 | MAPK1 (0.43) | P2RX7MAPK1CRHR1 | |
| SCHEMBL30989927 | 0.75 | PDE10A (0.51) | MAPK1GPR6CRHR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |