SCHEMBL30990326

SCHEMBL30990326

CCOC(=O)c1[nH]c2cc(Cl)oc2c1S(=O)(=O)Nc1ccc(C#N)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.37
▸ MAPT P10636 3/20 0.37
▸ THRB P10828 1/20 0.37
▸ TLR4 O00206 1/20 0.36
▸ ACLY P53396 1/20 0.35
▸ MAP2K1 Q02750 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ GALR3 O60755 1/20 0.35
▸ TUBB4A P04350 1/20 0.34
▸ TUBB P07437 1/20 0.34
▸ TUBA3C P0DPH7 1/20 0.34
▸ TUBA1B P68363 1/20 0.34
▸ TUBA4A P68366 1/20 0.34
▸ TUBB4B P68371 1/20 0.34
▸ TUBB3 Q13509 1/20 0.34
▸ TUBB2A Q13885 1/20 0.34
▸ TUBB8 Q3ZCM7 1/20 0.34
▸ TUBA3E Q6PEY2 1/20 0.34
▸ TUBA1A Q71U36 1/20 0.34
▸ TUBA1C Q9BQE3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30990199 0.87 ACLY (0.39) ACLYMAP2K1SIRT2
SCHEMBL30990295 0.74 ALOX15 (0.44) LMNAMAPTALDH1A1GALR3TUBB4A
SCHEMBL27412006 0.72 SLC22A12 (0.42) ACLYSIRT2
SCHEMBL30990197 0.66 ALOX15 (0.44) MAPTALDH1A1ALOX15KDM4EGAA
SCHEMBL21822255 0.66 ALOX15 (0.47) MAPTALDH1A1ALOX15KDM4EMEN1
SCHEMBL21822508 0.66 ALOX15 (0.53) MAPTALDH1A1ALOX15KDM4EGAA
SCHEMBL14654018 0.66 ALDH1A1 (0.50) LMNAMAPTALDH1A1TSHRKDM4E
SCHEMBL4178450 0.64 CA12 (0.47) MAPTTHRBMAP2K1ALDH1A1TSHR
SCHEMBL7447737 0.63 KDM4E (0.64) LMNAMAPTALDH1A1TSHRKDM4E
SCHEMBL21822329 0.62 ALOX15 (0.69) MAPTALDH1A1ALOX15KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4626860-A1 FUSED PYRROLYL-SULFONAMIDE COMPOUNDS ReWind Therapeutics NV (BE) 2025-10-08 — — EP disclosed
WO-2024115733-A1 FUSED PYRROLYL-SULFONAMIDE COMPOUNDS REWIND THERAPEUTICS NV (BE) 2024-06-06 — — WO disclosed
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