SCHEMBL30993286

SCHEMBL30993286

CC(C)(C)OC(=O)NC1CCCC1CN1C(=O)c2ccccc2C1=O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
BRD4 O60885 2/20 0.42
DRD2 P14416 2/20 0.41
KDM1A O60341 1/20 0.41
MAOB P27338 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
MEN1 O00255 2/20 0.40
KDM4E B2RXH2 1/20 0.40
PABPC1 P11940 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HPGD P15428 2/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPK1 P28482 1/20 0.39
KCNA3 P22001 1/20 0.39
EPHX2 P34913 1/20 0.38
BRD9 Q9H8M2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19790327 0.83 BRD4 (0.43) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL22348720 0.82 L3MBTL1 (0.46) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL22348717 0.82 L3MBTL1 (0.46) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL22348719 0.82 L3MBTL1 (0.46) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL24622983 0.82 L3MBTL1 (0.46) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL16524042 0.81 KMT2A (0.52) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL27504591 0.80 DRD2 (0.60) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL7583988 0.80 DRD2 (0.60) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL1987605 0.80 KMT2A (0.44) KMT2AL3MBTL1BRD4DRD2KDM1A
SCHEMBL14927029 0.80 KMT2A (0.44) KMT2AL3MBTL1BRD4DRD2KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130095-A9 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-08-02 WO disclosed
WO-2024130095-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-06-20 WO disclosed