Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | F11 | P03951 | 8/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28904292 | 0.84 | NOTUM (0.43) | NOTUMF11KLKB1KCNH2 | |
| SCHEMBL31544734 | 0.82 | F11 (0.42) | FLT3GSK3BNOTUMF11KLKB1 | |
| SCHEMBL30622090 | 0.82 | F11 (0.40) | FLT3GSK3BNOTUMF11KLKB1 | |
| SCHEMBL30995016 | 0.82 | NOTUM (0.41) | GSK3BNOTUMF11KLKB1KCNH2 | |
| SCHEMBL30995046 | 0.80 | F11 (0.41) | NOTUMF11KLKB1KCNH2 | |
| SCHEMBL24633365 | 0.79 | F11 (0.43) | F11KLKB1 | |
| SCHEMBL30995011 | 0.79 | F11 (0.43) | F11KLKB1 | |
| SCHEMBL31174046 | 0.78 | NOTUM (0.43) | NOTUMF11KLKB1KCNH2 | |
| SCHEMBL30995028 | 0.77 | F11 (0.47) | F11KLKB1 | |
| SCHEMBL30995006 | 0.77 | ALDH1A1 (0.49) | NOTUMF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126046-A | Substituted macrocyclic compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-04 | — | — | CN | disclosed |