Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976276 | 0.86 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL3970810 | 0.81 | AKT1 (0.32) | HSD11B1AKT1 | |
| SCHEMBL3970455 | 0.81 | ELOVL1 (0.35) | HSD11B1NPY5R | |
| SCHEMBL2973860 | 0.79 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL3970704 | 0.78 | HSD11B1 (0.33) | HSD11B1NPY5R | |
| SCHEMBL3978009 | 0.78 | ELOVL1 (0.33) | HSD11B1NPY5R | |
| SCHEMBL3977568 | 0.78 | HSD11B1 (0.33) | HSD11B1CYP2D6 | |
| SCHEMBL3974626 | 0.77 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL3977697 | 0.77 | CLK2 (0.35) | HSD11B1 | |
| SCHEMBL3907137 | 0.77 | PDE2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256114-A1 | Amido Compounds And Their Use As Pharmaceuticals | INCYTE CORPORATION (US) | 2010-10-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256114-A1 | Amido Compounds And Their Use As Pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | HSD11B1 1/4885CYP2D6 358/4885NPY5R 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.