Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.31 |
| ▸ | DLK1 | P80370 | 1/20 | 0.30 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972514 | 0.90 | MGLL (0.33) | HSD11B1ALDH1A1CYP3A4HPGDHSD17B10 | |
| SCHEMBL3973238 | 0.84 | GRIN2D (0.37) | HDAC1KCNH2 | |
| SCHEMBL3977568 | 0.81 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL3970810 | 0.78 | AKT1 (0.32) | HSD11B1ALDH1A1 | |
| SCHEMBL3099585 | 0.77 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL2973860 | 0.77 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL3970823 | 0.77 | MAPT (0.36) | HSD11B1ALDH1A1 | |
| SCHEMBL3976276 | 0.77 | HSD11B1 (0.37) | HDAC1KCNH2HSD11B1 | |
| SCHEMBL3907137 | 0.76 | PDE2A (0.32) | — | |
| SCHEMBL3972108 | 0.76 | HSD11B1 (0.33) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |