SCHEMBL30997381

SCHEMBL30997381

Fc1cnccc1CNc1nc(Cl)nn2cc(Br)cc12

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNH3 Q9ULD8 1/20 0.40
MAP4K4 O95819 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.33
TGFBR1 P36897 5/20 0.32
TGFBR2 P37173 1/20 0.32
BCDIN3D Q7Z5W3 1/20 0.32
ADRA2B P18089 1/20 0.30
JAK2 O60674 1/20 0.30
JAK1 P23458 1/20 0.30
JAK3 P52333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30997372 0.80 KCNH3 (0.41) KCNH3LOXL2TGFBR1
SCHEMBL30948885 0.78 RXFP1 (0.41) KCNH3
SCHEMBL31030118 0.77 HRH4 (0.32)
SCHEMBL31030098 0.76
SCHEMBL30997392 0.76 KCNH3 (0.41) KCNH3LOXL2TGFBR1TGFBR2BCDIN3D
SCHEMBL30997368 0.75 KCNH3 (0.34) KCNH3LOXL2
SCHEMBL31030142 0.74 HRH4 (0.31)
SCHEMBL31057896 0.72 SMN1; SMN2 (0.46)
SCHEMBL31010594 0.72 TLR7 (0.33) MAP4K4
SCHEMBL30980428 0.72 SMN1; SMN2 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4651950-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2025-11-26 EP disclosed
WO-2024155842-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. (US) 2024-07-25 WO disclosed