Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 19/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108321 | 0.89 | PTGS1 (0.85) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9252706 | 0.89 | PTGS1 (0.84) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9252681 | 0.89 | PTGS1 (0.84) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3103085 | 0.89 | ALOX5AP (0.69) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3096486 | 0.89 | PTGS1 (0.64) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3105521 | 0.87 | ALOX5AP (0.81) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL5100978 | 0.87 | ALOX5AP (0.67) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3105535 | 0.87 | ALOX5AP (0.69) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3095923 | 0.87 | ALOX5AP (0.69) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3099685 | 0.84 | ALOX5AP (0.63) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933842-B1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | PANMIRA PHARMACEUTICALS LLC (US) | 2012-10-03 | — | — | EP | disclosed |
| US-7795274-B2 | 5-lipoxygenase-activating protein (FLAP) inhibitors | AMIRA PHARMACEUTICALS INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20080227807-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-7405302-B2 | 5-lipoxygenase-activating protein (FLAP) inhibitors | AMIRA PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-20070123522-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227807-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885PTGS1 27/4885PTGS2 41/4885 |
| US-20070123522-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885PTGS1 27/4885PTGS2 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.