Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000157 | 0.78 | EIF2AK4 (0.34) | EIF2AK4 | |
| SCHEMBL31000239 | 0.75 | EIF2AK4 (0.34) | EIF2AK4 | |
| SCHEMBL17169818 | 0.72 | MKNK1 (0.34) | MKNK1MKNK2GRK5PIK3CDPIK3CB | |
| SCHEMBL31000273 | 0.72 | EIF2AK4 (0.43) | EIF2AK4PIK3CDPIK3CBPIK3CG | |
| SCHEMBL31000145 | 0.71 | NRAS (0.34) | EIF2AK4 | |
| SCHEMBL31000269 | 0.70 | EIF2AK4 (0.43) | EIF2AK4 | |
| SCHEMBL21209567 | 0.68 | EIF2AK4 (0.41) | MKNK1MKNK2EIF2AK4PIK3CDPIK3CB | |
| SCHEMBL17169824 | 0.68 | MKNK1 (0.56) | MKNK1MKNK2EIF2AK4GRK5PIK3CD | |
| SCHEMBL21193441 | 0.66 | EIF2AK4 (0.41) | MKNK1MKNK2EIF2AK4GRK5PIK3CD | |
| SCHEMBL31341123 | 0.63 | GABRA1 (0.37) | EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |