Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000195 | 0.90 | CFTR (0.36) | PDE4DCDK2JUNMAPK8MAPK9 | |
| SCHEMBL31000136 | 0.87 | PREP (0.34) | PDE4DCDK4CCND1CCND3CDK6 | |
| SCHEMBL31000268 | 0.87 | USP30 (0.37) | PDE4DCDK2JUNMAPK8MAPK9 | |
| SCHEMBL31000196 | 0.86 | CFTR (0.39) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL31000106 | 0.84 | CFTR (0.37) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL31000115 | 0.84 | CFTR (0.40) | PDE4DCDK2JUNMAPK8MAPK9 | |
| SCHEMBL31000149 | 0.84 | CFTR (0.39) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL31000204 | 0.81 | MAPK8 (0.38) | PDE4DCDK2JUNMAPK8MAPK9 | |
| SCHEMBL31000243 | 0.81 | CFTR (0.39) | CDK2CFTRIRAK4CCNT1CDK9 | |
| SCHEMBL31000072 | 0.79 | CDK4 (0.45) | CDK2CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |