Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000106 | 0.93 | CFTR (0.37) | CFTRCCNT1CDK9IDH1IGF1R | |
| SCHEMBL31000195 | 0.89 | CFTR (0.36) | CFTRCCNT1CDK9IGF1RCDK4 | |
| SCHEMBL31000149 | 0.88 | CFTR (0.39) | CFTRCCNT1CDK9IGF1RDNMT3A | |
| SCHEMBL31000174 | 0.88 | CDK4 (0.44) | CFTRTBK1CCNT1CDK9IDH1 | |
| SCHEMBL31000115 | 0.88 | CFTR (0.40) | CFTRCCNT1CDK9IGF1RCDK4 | |
| SCHEMBL31000138 | 0.86 | PDE4D (0.37) | CFTRCCNT1CDK9CDK4CCND1 | |
| SCHEMBL31000243 | 0.85 | CFTR (0.39) | CFTRCCNT1CDK9IGF1RPDE4B | |
| SCHEMBL31000194 | 0.82 | CFTR (0.38) | CFTRCCNT1CDK9IGF1RALK | |
| SCHEMBL31000268 | 0.82 | USP30 (0.37) | CFTRCCNT1CDK9PDE4BSYK | |
| SCHEMBL31000184 | 0.82 | FLT3 (0.39) | CCNT1CDK9IGF1RJUNCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |