Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000188 | 1.00 | PIK3CA (0.40) | PIK3CAPIK3R1ALKCDK4CCND1 | |
| SCHEMBL31000192 | 0.86 | CDK4 (0.42) | ALKCDK4CCND1CCND3CDK6 | |
| SCHEMBL31639210 | 0.85 | USP30 (0.38) | PIK3CAPIK3R1ALKCDK4CCND1 | |
| SCHEMBL31000209 | 0.82 | CDK4 (0.43) | ALKCDK4CCND1CCND3CDK6 | |
| SCHEMBL31639307 | 0.82 | TBK1 (0.38) | PIK3CAPIK3R1ALKUSP30LRRK2 | |
| SCHEMBL31000306 | 0.82 | GAA (0.40) | PIK3CACDK4CCND1CCND3CDK6 | |
| SCHEMBL31000072 | 0.82 | CDK4 (0.45) | ALKCDK4CCND1CCND3CDK6 | |
| SCHEMBL31000311 | 0.80 | CDK4 (0.45) | ALKCDK4CCND1CCND3CDK6 | |
| SCHEMBL31000233 | 0.80 | CDK4 (0.45) | ALKCDK4CCND1CCND3CDK6 | |
| SCHEMBL31000174 | 0.79 | CDK4 (0.44) | ALKCDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |