Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31009626 | 1.00 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL31009657 | 0.82 | ALDH1A1 (0.39) | CYP1A2CYP3A4CYP2D6CYP2C19JAK2 | |
| SCHEMBL31009656 | 0.82 | ALDH1A1 (0.39) | CYP1A2CYP3A4CYP2D6CYP2C19JAK2 | |
| SCHEMBL31009616 | 0.80 | KDM5A (0.40) | JAK2JAK1TYK2JAK3IKBKE | |
| SCHEMBL31009597 | 0.80 | KDM5A (0.40) | JAK2JAK1TYK2JAK3IKBKE | |
| SCHEMBL30784876 | 0.80 | KDM5A (0.40) | JAK2JAK1TYK2JAK3IKBKE | |
| SCHEMBL31009589 | 0.78 | IKBKE (0.36) | JAK2JAK1JAK3IKBKETBK1 | |
| SCHEMBL31009725 | 0.78 | IKBKE (0.36) | JAK2JAK1JAK3IKBKETBK1 | |
| SCHEMBL31009599 | 0.77 | CREBBP (0.39) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL31009606 | 0.77 | CREBBP (0.39) | JAK2JAK1TYK2JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246946-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246946-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | CYP1A2 840/4885CYP3A4 2123/4885CYP2D6 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.