Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.69 |
| ▸ | MAOB | P27338 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416054 | 0.88 | ROCK2 (0.67) | ROCK2ROCK1MAOBNPC1RAB9A | |
| SCHEMBL15147827 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL5441326 | 0.81 | MAOB (0.79) | ROCK2ROCK1MAOBPRKD3MAP4K4 | |
| SCHEMBL5407158 | 0.81 | MAOB (0.60) | ROCK2ROCK1MAOBPRKD3MAP4K4 | |
| SCHEMBL3104225 | 0.81 | L3MBTL1 (0.61) | MAOBL3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL3634175 | 0.80 | ROCK2 (0.62) | ROCK2ROCK1PRKD3MAP4K4CLK2 | |
| SCHEMBL5404361 | 0.80 | MAOB (0.59) | ROCK2ROCK1MAOBL3MBTL1PRKD3 | |
| SCHEMBL14514474 | 0.79 | MAOB (0.58) | ROCK2ROCK1MAOBPRKD3MAP4K4 | |
| SCHEMBL1247905 | 0.79 | RAB9A (0.63) | L3MBTL1NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL21490262 | 0.78 | ROCK2 (0.71) | ROCK2ROCK1MAOBPRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362056-B2 | 4-heteroaryl-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20100273850-A1 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA, INC. | 2010-10-28 | — | — | US | disclosed |
| WO-2009061730-A2 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID | ARRAY BIOPHARMA INC. (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273850-A1 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | CD22, HRH2, PTGDR2 | ROCK2 3037/4885ROCK1 4401/4885MAOB 2425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.