Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IL1B | P01584 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094460 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL3111861 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL3455872 | 0.77 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1L3MBTL1CHRM1 | |
| SCHEMBL1721491 | 0.75 | NPC1 (0.39) | SMN1; SMN2RAB9AALDH1A1NPC1L3MBTL1 | |
| SCHEMBL34468763 | 0.73 | SMYD3 (0.58) | RAB9AKDM4EALDH1A1NPC1L3MBTL1 | |
| SCHEMBL5139948 | 0.72 | HTT (0.60) | SMN1; SMN2RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL26098577 | 0.72 | CDK1 (0.59) | RAB9AALDH1A1NPC1L3MBTL1GAA | |
| SCHEMBL8396478 | 0.71 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9AALDH1A1NPC1L3MBTL1 | |
| SCHEMBL8395193 | 0.71 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9AALDH1A1NPC1L3MBTL1 | |
| SCHEMBL15945348 | 0.71 | HTT (0.63) | SMN1; SMN2RAB9AKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234372-A1 | SUBSTITUTED 2-MERCAPTOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234372-A1 | SUBSTITUTED 2-MERCAPTOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNJ2 | SMN1; SMN2 4161/4885RAB9A 4377/4885KDM4E 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.