⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31023806 | 0.77 | SLC5A2 (0.30) | — | |
| SCHEMBL31023918 | 0.70 | OPRD1 (0.36) | — | |
| SCHEMBL31023883 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL31023911 | 0.69 | OPRM1 (0.38) | — | |
| SCHEMBL31023870 | 0.67 | SRD5A2 (0.51) | — | |
| SCHEMBL31023706 | 0.66 | OPRD1 (0.33) | — | |
| SCHEMBL13684320 | 0.65 | ALDH1A1 (0.42) | — | |
| SCHEMBL3642753 | 0.65 | TSHR (0.53) | — | |
| SCHEMBL3456941 | 0.65 | KDM4E (0.53) | — | |
| SCHEMBL3641137 | 0.62 | PRKCI (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665718-A1 | SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF | Apogee Pharmaceuticals, Inc. (CA) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024168426-A1 | SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF | APOGEE PHARMACEUTICALS, INC. (CA) | 2024-08-22 | — | — | WO | disclosed |