Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31025500 | 0.85 | ADORA3 (0.34) | POLBADORA3ADORA2AADORA1LMNA | |
| SCHEMBL31025439 | 0.84 | POLB (0.32) | SMN1; SMN2POLBADORA3ADORA2AADORA1 | |
| SCHEMBL31025560 | 0.81 | TP53 (0.41) | ADORA3ADORA2AADORA1MAPTRXFP1 | |
| SCHEMBL31025517 | 0.78 | HRH4 (0.38) | SMN1; SMN2POLBADORA3ADORA2AADORA1 | |
| SCHEMBL31025498 | 0.75 | POLB (0.34) | SMN1; SMN2POLBADORA3ADORA2AADORA1 | |
| SCHEMBL31025479 | 0.75 | NPY5R (0.31) | NPY5RTP53 | |
| Hydrochloric Acid SCHEMBL31025649 | 0.73 | NPY5R (0.35) | POLBADORA3ADORA2AADORA1NPY5R | |
| SCHEMBL31025502 | 0.71 | THRB (0.43) | POLBADORA3ADORA2AADORA1NPY5R | |
| SCHEMBL31025486 | 0.69 | LMNA (0.33) | SMN1; SMN2ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL31025529 | 0.67 | NPC1 (0.33) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658657-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | Mirati Therapeutics, Inc. (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163707-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | Mirati Therapeutics, Inc. (US) | 2024-08-08 | — | — | WO | disclosed |