Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16036628 | 0.84 | LPL (0.35) | CA1CA2CA9ALOX15GFER | |
| SCHEMBL29556208 | 0.84 | LPL (0.35) | CA1CA2CA9ALOX15GFER | |
| SCHEMBL25367719 | 0.84 | MEN1 (0.36) | CA1CA2CA9ALOX15GFER | |
| SCHEMBL25436535 | 0.84 | LMNA (0.36) | CA1CA2CA9HIF1APTGER4 | |
| SCHEMBL28961843 | 0.82 | CXCR2 (0.42) | CA1CA2CA9HIF1AUCHL1 | |
| SCHEMBL31114631 | 0.82 | CXCR2 (0.42) | CA1CA2CA9HIF1AUCHL1 | |
| SCHEMBL26117053 | 0.81 | NPC1 (0.42) | CA1CA2CA9HIF1AALOX15 | |
| SCHEMBL31200582 | 0.81 | NPC1 (0.42) | CA1CA2CA9HIF1AALOX15 | |
| SCHEMBL27171762 | 0.81 | MEN1 (0.36) | CA1CA2CA9UCHL1MAPT | |
| SCHEMBL16382848 | 0.81 | LPL (0.35) | CA1CA2CA9HIF1AUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658654-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINES AND PYRAZOLO[1,5-D] [1,2,4]TRIAZINES AS NLRP3 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160691-A1 | PYRROLO[1,2-d][1,2,4]TRIAZINES AND PYRAZOLO[1,5-d] [1,2,4]TRIAZINES AS NLRP3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-08-08 | — | — | WO | disclosed |