⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366633 | 0.79 | TSHR (0.43) | — | |
| SCHEMBL29097366 | 0.74 | — | — | |
| SCHEMBL28906947 | 0.64 | L3MBTL1 (0.42) | — | |
| SCHEMBL23726349 | 0.62 | — | — | |
| SCHEMBL21777296 | 0.62 | — | — | |
| SCHEMBL21777297 | 0.62 | — | — | |
| SCHEMBL2513938 | 0.62 | RIPK1 (0.30) | — | |
| SCHEMBL28597498 | 0.62 | POLB (0.31) | — | |
| SCHEMBL2487318 | 0.60 | LMNA (0.34) | — | |
| SCHEMBL18979169 | 0.60 | LMNA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658667-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | Merck Sharp & Dohme LLC (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163691-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | MERCK SHARP & DOHME LLC (US) | 2024-08-08 | — | — | WO | disclosed |