Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087754 | 1.00 | JAK2 (0.45) | JAK2RPS6KA3MELKSTK24BACE1 | |
| SCHEMBL29374267 | 0.81 | ALDH1A1 (0.53) | BACE1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29349435 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL1187339 | 0.81 | ALDH1A1 (0.53) | BACE1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL65699 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL8878160 | 0.79 | CYP3A4 (0.42) | JAK2RPS6KA3MELKSTK24BACE1 | |
| SCHEMBL14742902 | 0.78 | ALDH1A1 (0.59) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Hydrochloric Acid SCHEMBL11277860 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL2638226 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL9627127 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118451068-A | Tri-fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |