Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31038488 | 1.00 | JAK2 (0.45) | JAK2RPS6KA3MELKSTK24BACE1 | |
| SCHEMBL29374267 | 0.81 | ALDH1A1 (0.53) | BACE1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29349435 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL1187339 | 0.81 | ALDH1A1 (0.53) | BACE1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL65699 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL8878160 | 0.79 | CYP3A4 (0.42) | JAK2RPS6KA3MELKSTK24BACE1 | |
| SCHEMBL14742902 | 0.78 | ALDH1A1 (0.59) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Hydrochloric Acid SCHEMBL11277860 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL2638226 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL9627127 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114349684-A | Synthetic method of benzo [ c, d ] indole imine derivative | 西南林业大学 | 2022-04-15 | — | — | CN | claimed |
| CN-113856581-A | Preparation device and method of 8-bromo-1-naphthylamine | 武汉青风凯默生物医药科技有限公司 | 2021-12-31 | — | — | CN | claimed |
| US-12503481-B2 | Three-dimensional organic sandwich chirality and its synthetic assembly | TEXAS TECH UNIVERSITY SYSTEM (US) | 2025-12-23 | — | — | US | disclosed |
| CN-119350335-B | Material with benzopyridine acridine structure and application thereof | 烟台九目化学股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| US-20250059196-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2025-02-20 | — | — | US | disclosed |
| CN-119350335-A | Material with benzopyridine acridine structure and application thereof | 烟台九目化学股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| EP-4458819-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2024-11-06 | — | — | EP | disclosed |
| CN-118373822-B | Material containing benzopyrrole acridine structure and application thereof | 烟台九目化学股份有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-118373822-A | Material containing benzopyrrole acridine structure and application thereof | 烟台九目化学股份有限公司 | 2024-07-23 | — | — | CN | disclosed |
| US-20240182470-A1 | KRASG12C MUTANT PROTEIN INHIBITOR, PREARATION AND USE THEREOF | YA THERAPEUTICS INC (CN) | 2024-06-06 | — | — | US | disclosed |
| CN-115181106-B | Quinazoline KRAS G12D Preparation and application of mutant protein inhibitor | 药雅科技(上海)有限公司 | 2024-04-05 | — | — | CN | disclosed |
| US-20060287309-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| US-20060287310-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| CN-1863784-A | 2-naphthylimino-1,3-thiazine derivative | SHIONOGI & CO (JP) | 2006-11-15 | — | — | CN | disclosed |
| EP-1660497-A1 | [ 1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005019215-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050043309-A1 | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia | WARNER-LAMBERT COMPANY LLC | 2005-02-24 | — | — | US | disclosed |
| EP-0225175-A2 | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-06-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240182470-A1 | KRASG12C MUTANT PROTEIN INHIBITOR, PREARATION AND USE THEREOF | KRAS, NRAS, HRAS | JAK2 305/4885RPS6KA3 703/4885MELK 1165/4885 |
| US-20050043309-A1 | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia | DRD1, DRD2, DRD3 | JAK2 2165/4885RPS6KA3 1595/4885MELK 4158/4885 |
| US-12503481-B2 | Three-dimensional organic sandwich chirality and its synthetic assembly | WNT3, CTNNB1, ORC3 | JAK2 3574/4885RPS6KA3 2966/4885MELK 1934/4885 |
| US-20250059196-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | WEE1, CYP51A1, WEE2 | JAK2 1764/4885RPS6KA3 4402/4885MELK 4433/4885 |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | JAK2 175/4885RPS6KA3 2227/4885MELK 3543/4885 |
| US-20060287309-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | DRD1, DRD2, DRD3 | JAK2 2165/4885RPS6KA3 1595/4885MELK 4158/4885 |
| US-20060287310-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | DRD1, DRD2, DRD3 | JAK2 2165/4885RPS6KA3 1595/4885MELK 4158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.