Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039741 | 1.00 | NLRP3 (0.41) | NLRP3GFERKAT2BALDH1A1ROCK2 | |
| SCHEMBL31341807 | 0.84 | ROCK2 (0.45) | NLRP3KAT2BROCK2ROCK1 | |
| SCHEMBL29159546 | 0.81 | CAMK2D (0.45) | NLRP3KAT2B | |
| SCHEMBL24695702 | 0.81 | CAMK2D (0.45) | NLRP3KAT2B | |
| SCHEMBL27292457 | 0.81 | NLRP3 (0.55) | NLRP3KAT2BROCK2ROCK1 | |
| SCHEMBL31039762 | 0.79 | NLRP3 (0.56) | NLRP3KAT2BROCK2ROCK1 | |
| SCHEMBL31039735 | 0.79 | KAT2B (0.53) | NLRP3KAT2BROCK2ROCK1 | |
| SCHEMBL31039722 | 0.77 | NLRP3 (0.61) | NLRP3KAT2BROCK2ROCK1 | |
| SCHEMBL31039746 | 0.76 | NLRP3 (0.43) | NLRP3KAT2BROCK2 | |
| SCHEMBL31039693 | 0.76 | NLRP3 (0.78) | NLRP3GFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630417-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. Hoffmann-La Roche AG (CH) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024121086-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. HOFFMANN-LA ROCHE AG (CH) | 2024-06-13 | — | — | WO | disclosed |