Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.44 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 2/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24695702 | 0.83 | CAMK2D (0.45) | NLRP3KAT2BIL1BCAMK2D | |
| SCHEMBL29159546 | 0.83 | CAMK2D (0.45) | NLRP3KAT2BIL1BCAMK2D | |
| SCHEMBL31039735 | 0.82 | KAT2B (0.53) | NLRP3CCNKCDK7CCNHMNAT1 | |
| SCHEMBL31341807 | 0.81 | ROCK2 (0.45) | NLRP3KAT2BROCK2CAMK2DROCK1 | |
| SCHEMBL27292457 | 0.80 | NLRP3 (0.55) | NLRP3CCNKCDK7CCNHMNAT1 | |
| SCHEMBL31039762 | 0.78 | NLRP3 (0.56) | NLRP3CCNKCDK7CCNHMNAT1 | |
| SCHEMBL31039733 | 0.78 | NLRP3 (0.41) | NLRP3CCNKCDK7CCNHMNAT1 | |
| SCHEMBL31341805 | 0.77 | NLRP3 (0.40) | NLRP3CCNKCDK7CCNHMNAT1 | |
| SCHEMBL25294649 | 0.76 | KAT2B (0.45) | NLRP3CCNKCDK12KAT2BCCNT1 | |
| SCHEMBL25294648 | 0.76 | KAT2B (0.45) | NLRP3CCNKCDK12KAT2BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630417-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. Hoffmann-La Roche AG (CH) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024121086-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. HOFFMANN-LA ROCHE AG (CH) | 2024-06-13 | — | — | WO | disclosed |