Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318812 | 0.87 | LTA4H (0.65) | LTA4HHRH3TEAD3KDM4EHTT | |
| SCHEMBL6942319 | 0.83 | TEAD3 (0.56) | LTA4HHRH3TEAD3KDM4EALDH1A1 | |
| SCHEMBL1706813 | 0.83 | KDM4E (0.57) | LTA4HKDM4E | |
| SCHEMBL7289138 | 0.83 | KDM4E (0.57) | LTA4HKDM4E | |
| SCHEMBL22440218 | 0.82 | LTA4H (0.77) | LTA4HHRH3TEAD3NPC1RAB9A | |
| SCHEMBL25285380 | 0.80 | SLC6A3 (0.61) | LTA4H | |
| SCHEMBL21197752 | 0.80 | SLC6A3 (0.61) | LTA4H | |
| SCHEMBL27350521 | 0.80 | SLC6A3 (0.61) | LTA4H | |
| SCHEMBL8109363 | 0.79 | LTA4H (0.55) | LTA4HHRH3TEAD3NPC1RAB9A | |
| SCHEMBL6947336 | 0.79 | LTA4H (0.55) | LTA4HHRH3TEAD3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630417-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. Hoffmann-La Roche AG (CH) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024121086-A1 | NOVEL COMPOUNDS AS MODULATORS OF NLRP3 INHIBITION | F. HOFFMANN-LA ROCHE AG (CH) | 2024-06-13 | — | — | WO | disclosed |