Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524152 | 0.83 | NEK2 (0.67) | NEK2KMT2AKDM4ECYP2C19RECQL | |
| SCHEMBL2560551 | 0.82 | KMT2A (0.54) | KMT2AKDM4ECYP2C19RECQLMALT1 | |
| SCHEMBL883905 | 0.82 | KMT2A (0.58) | KMT2AKDM4ECYP2C19RECQLMEN1 | |
| SCHEMBL2421306 | 0.81 | MALT1 (0.70) | NEK2KMT2AKDM4ECYP2C19MALT1 | |
| SCHEMBL28189129 | 0.81 | KMT2A (0.60) | KMT2ACYP2C19MEN1CYP1A2CYP3A4 | |
| SCHEMBL29173062 | 0.81 | KMT2A (0.52) | KMT2AKDM4ECYP2C19RECQLMEN1 | |
| SCHEMBL29421198 | 0.81 | KMT2A (0.52) | KMT2AKDM4ECYP2C19RECQLMEN1 | |
| SCHEMBL29835066 | 0.81 | KMT2A (0.52) | KMT2AKDM4ECYP2C19RECQLMEN1 | |
| SCHEMBL238160 | 0.80 | KDM4E (0.60) | NEK2KMT2AKDM4ECYP2C19RECQL | |
| SCHEMBL4879872 | 0.80 | KDM4E (0.60) | NEK2KMT2AKDM4ECYP2C19RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | NEK2 441/4885KMT2A 1488/4885KDM4E 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.